γ-interferon, retinoic acid, and cytosine arabinoside induce neuroblastoma differentiation by different mechanisms

1. The effects of gamma-interferon (γ-IFN), retinoic acid (RA), and cytosine arabinoside (ARA-C) on the growth, morphology, and phenotype of the human neuroblastoma (NB) cell lines, LAN-1 and GI-ME-N, have been extensively tested. 2. RA,γ-IFN, and ARA-C induced a dose-dependent morphological differentiation and growth inhibition, without affecting cell… CONTINUE READING