γ-Sitosterol from Acacia nilotica L. induces G2/M cell cycle arrest and apoptosis through c-Myc suppression in MCF-7 and A549 cells.

@article{Sundarraj2012SitosterolFA,
  title={γ-Sitosterol from Acacia nilotica L. induces G2/M cell cycle arrest and apoptosis through c-Myc suppression in MCF-7 and A549 cells.},
  author={Shenbagamoorthy Sundarraj and Ramar Thangam and Vellingiri Sreevani and Krishnasamy Kaveri and Palani Gunasekaran and Shanmugam Achiraman and Soundarapandian Kannan},
  journal={Journal of ethnopharmacology},
  year={2012},
  volume={141 3},
  pages={
          803-9
        }
}
ETHNOPHARMACOLOGICAL RELEVANCE Acacia nilotica is widely distributed in Asia. In India, it occupies an important place in the indigenous system of medicine against anti-inflammatory, antioxidant, cancers, and/or tumors. AIM OF THE STUDY The purpose of this study is to investigate the inhibitory effect of Acacia nilotica leaves extract and γ-Sitosterol on cell proliferation, the apoptotic effect and cell cycle arrest in breast and lung cancer cells. MATERIALS AND METHODS GC-MS and HPLC were… CONTINUE READING

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