γ-Secretase-regulated signaling typified by Notch signaling in the immune system.

@article{Nagase2013SecretaseregulatedST,
  title={γ-Secretase-regulated signaling typified by Notch signaling in the immune system.},
  author={Hisashi Nagase and Kohzo Nakayama},
  journal={Current stem cell research & therapy},
  year={2013},
  volume={8 5},
  pages={341-56}
}
Notch signaling mediates the fates of numerous cells not only in the nervous system but also in the immune system. Notch signaling contributes to the generation and maintenance of hematopoietic stem cells, lymphocyte development, and several immune responses. The molecular mechanism of Notch signaling is unique: ligands bind to the extracellular domain of… CONTINUE READING