γ-Secretase inhibitors and modulators for Alzheimer's disease.

Abstract

γ-Secretase is a membrane embedded aspartyl protease complex with presenilin as the catalytic component. Along with β-secretase, this enzyme produces the amyloid β-protein of Alzheimer's disease (AD) from the amyloid β-protein precursor. Because of its key role in the pathogenesis of AD, γ-secretase has been a prime target for drug discovery, and many… (More)
DOI: 10.1111/j.1471-4159.2011.07501.x

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