γ-Secretase inhibitor enhances antitumour effect of radiation in Notch-expressing lung cancer

@inproceedings{Mizugaki2012SecretaseIE,
  title={γ-Secretase inhibitor enhances antitumour effect of radiation in Notch-expressing lung cancer},
  author={Hidenori Mizugaki and Jun Sakakibara-Konishi and Yasuyuki Ikezawa and Junko Kikuchi and Eiki Kikuchi and Satoshi Oizumi and Thao P. Dang and Miyako Nishimura},
  booktitle={British Journal of Cancer},
  year={2012}
}
Background:Notch receptor has an important role in both development and cancer. We previously reported that inhibition of the Notch3 by γ-secretase inhibitor (GSI) induces apoptosis and suppresses tumour proliferation in non-small-cell lung cancer. Although radiation is reported to induce Notch activation, little is known about the relationship between radiation and Notch pathway.Methods:We examined the effect of combining GSI and radiation at different dosing in three Notch expressing lung… CONTINUE READING