γ-Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase

@article{Ni2001SecretaseCA,
  title={$\gamma$-Secretase Cleavage and Nuclear Localization of ErbB-4 Receptor Tyrosine Kinase},
  author={Chang-Yuan Ni and Michael Paul Murphy and Todd E. Golde and Graham Carpenter},
  journal={Science},
  year={2001},
  volume={294},
  pages={2179 - 2181}
}
ErbB-4 is a transmembrane receptor tyrosine kinase that regulates cell proliferation and differentiation. After binding of its ligand heregulin (HRG) or activation of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA), the ErbB-4 ectodomain is cleaved by a metalloprotease. We now report a subsequent cleavage by γ-secretase that releases the ErbB-4 intracellular domain from the membrane and facilitates its translocation to the nucleus. γ-Secretase cleavage was prevented by… 
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