γ-Sarcoglycan Deficiency Leads to Muscle Membrane Defects and Apoptosis Independent of Dystrophin

@article{Hack1998SarcoglycanDL,
  title={γ-Sarcoglycan Deficiency Leads to Muscle Membrane Defects and Apoptosis Independent of Dystrophin },
  author={Andrew A. Hack and Chantal T. Ly and Fang Chun Jiang and Cynthia J. Clendenin and Kirsten S. Sigrist and Robert L. Wollmann and E. M. McNally},
  journal={The Journal of Cell Biology},
  year={1998},
  volume={142},
  pages={1279 - 1287}
}
gamma-Sarcoglycan is a transmembrane, dystrophin-associated protein expressed in skeletal and cardiac muscle. The murine gamma-sarcoglycan gene was disrupted using homologous recombination. Mice lacking gamma-sarcoglycan showed pronounced dystrophic muscle changes in early life. By 20 wk of age, these mice developed cardiomyopathy and died prematurely. The loss of gamma-sarcoglycan produced secondary reduction of beta- and delta-sarcoglycan with partial retention of alpha- and epsilon… CONTINUE READING

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