γ-MYN: a new algorithm for estimating Ka and Ks with consideration of variable substitution rates

@article{Wang2009MYNAN,
  title={γ-MYN: a new algorithm for estimating Ka and Ks with consideration of variable substitution rates},
  author={Dapeng Wang and Haolei Wan and Song Zhang and Jun Jie Yu},
  journal={Biology Direct},
  year={2009},
  volume={4},
  pages={20 - 20}
}
Over the past two decades, there have been several approximate methods that adopt different mutation models and used for estimating nonsynonymous and synonymous substitution rates (Ka and Ks) based on protein-coding sequences across species or even different evolutionary lineages. Among them, MYN method (a Modified version of Yang-Nielsen method) considers three major dynamic features of evolving DNA sequences–bias in transition/transversion rate, nucleotide frequency, and unequal transitional… CONTINUE READING
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