γ-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins

@article{Luster1985InterferonTR,
  title={$\gamma$-Interferon transcriptionally regulates an early-response gene containing homology to platelet proteins},
  author={Andrew D. Luster and Jay C. Unkeless and Jeffrey V. Ravetch},
  journal={Nature},
  year={1985},
  volume={315},
  pages={672-676}
}
Interferons are a family of proteins first identified by their ability to induce cellular resistance to infection by many viruses. In addition to the antiviral properties it shares with the α- and β-interferons, γ-interferon (IFN-γ), a lymphokine secreted by activated T cells, activates macrophages, stimulates B cells, increases fibroblast and endothelial cell resistance to many non-viral intracellular parasites and modulates cell-surface proteins central to immune cell regulation1–13. To… Expand
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It is shown that murine IFN-γ produced by recombinant DNA technology shows similar biological effects to BMFs from two other sources, and may be one of several molecules with a direct role in driving the maturation of resting B cells to active immunoglobulin secretion. Expand
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It is found that for several antigens, administration of IFN-γ to mice leads to two- to five-fold enhancement of antibody formation provided that the IFn-γ and antigen are administered together. Expand
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It is demonstrated here that cloned murine IFN-γ can also substitute for a late-acting helper factor which acts synergistically with other helper factors in the stimulation of B-cell antibody responses in vitro. Expand
Preferential effect of γ interferon on the synthesis of HLA antigens and their mRNAs in human cells
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Interferons from stimulated human lymphocytes and from monkey cells transfected by cloned human IFN-γ cDNA induced the HLA-A,B,C and β2-microglobulin mRNAs or proteins at concentrations over 100 times lower than those needed to induce the (2′–5′)oligo(A) synthetase and the antiviral state. Expand
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It is shown conclusively by using mouse gamma interferon (MulFN-gamma)3 produced by recombinant DNA technology that this lymphokine has the capacity to induce the priming step in the process of macrophage activation for tumor cell killing. Expand
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TLDR
It is reported that murine IFN-γ that had been cloned and expressed in a simian nonlymphoid cell line shows MAF activity, but it is not yet known whether IFn-γ is responsible for all the MAFActivity in media conditioned by T cells as the possibility for MAF heterogeneity remains. Expand
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TLDR
A close correlation was found between the presence of IFN-gamma activity demonstrable in an antiviral assay and MAF activity in individual fractions and the ability of various human IFN to activate monocytes. Expand
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TLDR
IFN gamma activates human macrophage oxidative metabolism and antimicrobial activity, and appeared to be the only factor consistently capable of doing so in the diverse LK preparations tested. Expand
Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells
Eighteen cDNAs, cloned from interferon-treated T98G neuroblastoma cells, correspond to seven different mRNAs induced up to 40-fold by interferon. One codes for metallothionein II and another for aExpand
Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.
  • E. Pfefferkorn
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1984
TLDR
Several hypotheses are presented to explain how the intracellular degradation of tryptophan induced by gamma interferon could restrict the growth of an obligate intrACEllular parasite. Expand
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