γ-Hydroxybutyric acid induces oxidative stress in cerebral cortex of young rats

@article{Sgaravatti2007HydroxybutyricAI,
  title={$\gamma$-Hydroxybutyric acid induces oxidative stress in cerebral cortex of young rats},
  author={{\^A}ngela Malysz Sgaravatti and Mirian Bonaldi Sgarbi and Carla G. Testa and Karina Durigon and Carolina Didonet Pederzolli and Cristina C. Prestes and Angela T.S. Wyse and Clovis Milton Duval Wannmacher and Moacir Wajner and Carlos Severo Dutra-filho},
  journal={Neurochemistry International},
  year={2007},
  volume={50},
  pages={564-570}
}

Effects of 1,4-butanediol administration on oxidative stress in rat brain: Study of the neurotoxicity of γ-hydroxybutyric acid in vivo

Results indicate that 1,4-BD induces in vivo oxidative stress by stimulating lipid peroxidation and decreasing the non-enzymatic antioxidant defenses in cerebral cortex of young rats.

Promotion of Lipid and Protein Oxidative Damage in Rat Brain by Ethylmalonic Acid

In the present work, the in vitro effect of EMA on oxidative stress parameters in rat cerebral cortex is investigated and it is presumed that oxidative stress may represent a pathomechanism involved in the pathophysiology of the neurologic symptoms manifested by patients affected by disorders in which EMA accumulates.

Evaluation of the Effects of Fructose on Oxidative Stress and Inflammatory Parameters in Rat Brain

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Evidence for oxidative stress in tissues derived from succinate semialdehyde dehydrogenase-deficient mice

The data showing an imbalance between tissue antioxidant defences and oxidative attack strongly indicate that oxidative stress is involved in the pathophysiology of SSADH deficiency in mice, and likely the corresponding human disorder.

Oxidative stress induction by cis-4-decenoic acid: Relevance for MCAD deficiency

The data indicate that oxidative stress is induced by cDA in rat brain in vitro and that oxidative damage might be involved in the pathophysiology of the encephalopathy in MCADD.

Neurotoxic effects induced by gammahydroxybutyric acid (GHB) in male rats.

The results show for the first time that the repeated administration of GHB, especially at very low doses, produces neurotoxic effects, which is very relevant because its abuse, especially by young persons, could produce considerable neurological alterations after prolonged abuse.

Succinic semialdehyde dehydrogenase: biochemical-molecular-clinical disease mechanisms, redox regulation, and functional significance.

The current review summarizes some 30 years of research on this protein and disease, addressing pathological mechanisms in human and mouse at the protein, metabolic, molecular, and whole-animal level.

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Succinic semialdehyde dehydrogenase (SSADH) deficiency is a rare disorder characterized by an inborn error of the catabolism of the inhibitory neurotransmitter GABA. Because of the deficiency of

Inhibition of Rat Brain Lipid Synthesis In Vitro by 4-Hydroxybutyric Acid

Evaluated the in vitro influence of 4HB on lipid synthesis and CO2 production from [U-14C] acetate in cerebral cortex of 30-day-old Wistar rats found an impairment of mitochondrial metabolism by 4HB which may secondarily inhibit lipid synthesis.

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