γ-Hydroxybutyric acid induces oxidative stress in cerebral cortex of young rats

@article{Sgaravatti2007HydroxybutyricAI,
  title={γ-Hydroxybutyric acid induces oxidative stress in cerebral cortex of young rats},
  author={{\^A}. M. Sgaravatti and M. B. Sgarbi and C. G. Testa and K. Durigon and C. Dutra-Filho},
  journal={Neurochemistry International},
  year={2007},
  volume={50},
  pages={564-570}
}
  • Â. M. Sgaravatti, M. B. Sgarbi, +2 authors C. Dutra-Filho
  • Published 2007
  • Chemistry, Medicine
  • Neurochemistry International
    • GHB is a naturally occurring compound in the central nervous system (CNS) whose tissue concentration are highly increased during drug abuse and in the inherited deficiency of succinic semialdehyde dehydrogenase (SSADH) activity. SSADH deficiency is a neurometabolic-inherited disorder of the degradation pathway of gamma-aminobutyric acid (GABA). It is biochemically characterized by increased concentrations of gamma-hydroxybutyric acid (GHB) in tissues, cerebrospinal fluid (CSF), blood and urine… CONTINUE READING
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    References

    SHOWING 1-10 OF 43 REFERENCES
    Significance of γ-hydroxybutyric acid in the brain
    • 82
    Murine succinate semialdehyde dehydrogenase deficiency
    • 51
    Significant behavioral disturbances in succinic semialdehyde dehydrogenase (SSADH) deficiency (Gamma-Hydroxybutyric aciduria)
    • 102
    Vigabatrin and newer interventions in succinic semialdehyde dehydrogenase deficiency
    • 57
    • PDF
    Inhibition of Rat Brain Lipid Synthesis In Vitro by 4-Hydroxybutyric Acid
    • 11
    Therapeutic intervention in mice deficient for succinate semialdehyde dehydrogenase (gamma-hydroxybutyric aciduria).
    • 75
    • PDF
    Increased guanidino species in murine and human succinate semialdehyde dehydrogenase (SSADH) deficiency.
    • 32
    Succinic semialdehyde dehydrogenase deficiency in children and adults
    • 120
    Inhibition of succinic semialdehyde dehydrogenase activity by alkenal products of lipid peroxidation.
    • 47
    Inherited disorders of GABA metabolism
    • 79