γ-Hydroxybutyric acid induces oxidative stress in cerebral cortex of young rats

@article{Sgaravatti2007HydroxybutyricAI,
  title={γ-Hydroxybutyric acid induces oxidative stress in cerebral cortex of young rats},
  author={{\^A}. M. Sgaravatti and M. B. Sgarbi and C. G. Testa and K. Durigon and C. Dutra-Filho},
  journal={Neurochemistry International},
  year={2007},
  volume={50},
  pages={564-570}
}
  • Â. M. Sgaravatti, M. B. Sgarbi, +2 authors C. Dutra-Filho
  • Published 2007
  • Chemistry, Medicine
  • Neurochemistry International
  • GHB is a naturally occurring compound in the central nervous system (CNS) whose tissue concentration are highly increased during drug abuse and in the inherited deficiency of succinic semialdehyde dehydrogenase (SSADH) activity. SSADH deficiency is a neurometabolic-inherited disorder of the degradation pathway of gamma-aminobutyric acid (GABA). It is biochemically characterized by increased concentrations of gamma-hydroxybutyric acid (GHB) in tissues, cerebrospinal fluid (CSF), blood and urine… CONTINUE READING
    43 Citations
    Effects of 1,4-butanediol administration on oxidative stress in rat brain: Study of the neurotoxicity of γ-hydroxybutyric acid in vivo
    • 24
    Promotion of Lipid and Protein Oxidative Damage in Rat Brain by Ethylmalonic Acid
    • 14
    Evidence for oxidative stress in tissues derived from succinate semialdehyde dehydrogenase-deficient mice
    • 33
    • Highly Influenced
    Oxidative stress induction by cis-4-decenoic acid: Relevance for MCAD deficiency
    • 20
    Neurotoxic effects induced by gammahydroxybutyric acid (GHB) in male rats.
    • 33
    • PDF

    References

    SHOWING 1-10 OF 43 REFERENCES
    Murine succinate semialdehyde dehydrogenase deficiency
    • 51
    Inhibition of Rat Brain Lipid Synthesis In Vitro by 4-Hydroxybutyric Acid
    • 11
    Therapeutic intervention in mice deficient for succinate semialdehyde dehydrogenase (gamma-hydroxybutyric aciduria).
    • 75
    • PDF
    Increased guanidino species in murine and human succinate semialdehyde dehydrogenase (SSADH) deficiency.
    • 32
    Inherited disorders of GABA metabolism
    • 79