• DOI:10.1016/j.neuropharm.2004.08.019
Corpus ID: 54233206

γ-Hydroxybutyric acid (GHB) and γ-aminobutyric acidB receptor (GABABR) binding sites are distinctive from one another: molecular evidence

@article{Wu2004HydroxybutyricA,
  title={γ-Hydroxybutyric acid (GHB) and γ-aminobutyric acidB receptor (GABABR) binding sites are distinctive from one another: molecular evidence},
  author={Y. Wu and S. Ali and G. Ahmadian and C. Liu and O. Snead},
  journal={Neuropharmacology},
  year={2004},
  volume={47},
  pages={1146-1156}
}

Y. Wu, S. Ali, +2 authors O. Snead

Published 2004

Biology

Neuropharmacology

Abstract γ-Hydroxybutyric Acid (GHB) is thought to be a weak partial agonist at the γ-aminobutyric acidB Receptor (GABABR), but the precise relationship of the GHB receptor (GHBR) to the GABABR remains unclear. In order to test the hypothesis that the GHBR is not identical to the GABABR, we conducted two groups of experiments. First, GABABR subtype 1 (R1) and/or subtype 2 (R2) were over expressed in HEK 293 cells and membrane binding studies on the transfected cells done using [3H]GHB and [3H… CONTINUE READING

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