γ-Hydroxybutyrate and the GABAergic footprint: a metabolomic approach to unpicking the actions of GHB.

@article{Nasrallah2010HydroxybutyrateAT,
  title={γ-Hydroxybutyrate and the GABAergic footprint: a metabolomic approach to unpicking the actions of GHB.},
  author={Fatima A. Nasrallah and Anthony D. Maher and J. Robert Hanrahan and Vladimir Josef Balcar and Caroline D Rae},
  journal={Journal of neurochemistry},
  year={2010},
  volume={115 1},
  pages={
          58-67
        }
}
Gamma-hydroxybutyrate is found both naturally in the brain and self-administered as a drug of abuse. It has been reported to act at endogenous γ-hydroxybutyrate (GHB) receptors and GABA(B) receptors [GABA(B)R], and may also be metabolized to GABA. Here, the metabolic fingerprints of a range of concentrations of GHB were measured in brain cortical tissue slices and compared with those of ligands active at GHB and GABA-R using principal components analysis (PCA) to identify sites of GHB activity… CONTINUE READING
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