γ-H2AX detection in peripheral blood lymphocytes, splenocytes, bone marrow, xenografts, and skin.

@article{Redon2011H2AXDI,
  title={γ-H2AX detection in peripheral blood lymphocytes, splenocytes, bone marrow, xenografts, and skin.},
  author={Christophe E. Redon and Asako J. Nakamura and Olivier Sordet and Jennifer S. Dickey and Ksenia Gouliaeva and Brian Tabb and Scott Lawrence and Robert J. Kinders and W. M. Bonner and Olga A. Sedelnikova},
  journal={Methods in molecular biology},
  year={2011},
  volume={682},
  pages={249-70}
}
Measurement of DNA double-strand break (DSB) levels in cells is useful in many research areas, including those related to DNA damage and repair, tumorigenesis, anti-cancer drug development, apoptosis, radiobiology, environmental effects, and aging, as well as in the clinic. DSBs can be detected in the nuclei of cultured cells and tissues with an antibody to H2AX phosphorylated on serine residue 139 (γ-H2AX). DSB levels can be obtained either by measuring overall γ-H2AX protein levels in a cell… CONTINUE READING

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