γ-Glutamylmethylamide Is an Essential Intermediate in the Metabolism of Methylamine by Methylocella silvestris

@article{Chen2010GlutamylmethylamideIA,
  title={γ-Glutamylmethylamide Is an Essential Intermediate in the Metabolism of Methylamine by Methylocella silvestris},
  author={Y. Chen and J. Scanlan and L. Song and Andrew Crombie and M. T. Rahman and H. Sch{\"a}fer and J. Murrell},
  journal={Applied and Environmental Microbiology},
  year={2010},
  volume={76},
  pages={4530 - 4537}
}
  • Y. Chen, J. Scanlan, +4 authors J. Murrell
  • Published 2010
  • Biology, Medicine
  • Applied and Environmental Microbiology
  • ABSTRACT Methylocella silvestris BL2, a facultative methane utilizer, can grow on monomethylamine (MMA) as a sole carbon and nitrogen source. No activity of MMA dehydrogenase was detectable. Instead, this bacterium utilizes a methylated amino acid pathway (γ-glutamylmethylamide [GMA] and N-methylglutamate [NMG]) for MMA metabolism. The activities of the two key enzymes in this pathway, GMA synthetase and NMG dehydrogenase, were found when the bacterium was grown on MMA. GMA was detected by high… CONTINUE READING
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