γ-Adducin stimulates the thiazide-sensitive NaCl cotransporter.

@article{Dimke2011AdducinST,
  title={γ-Adducin stimulates the thiazide-sensitive NaCl cotransporter.},
  author={Henrik Dimke and Pedro San-Cristobal and Mark J J de Graaf and Jacques W M Lenders and J. T. Deinum and Joost G. J. Hoenderop and Ren{\'e} J M Bindels},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2011},
  volume={22 3},
  pages={508-17}
}
The thiazide-sensitive NaCl cotransporter (NCC) plays a key role in renal salt reabsorption and the determination of systemic BP, but the molecular mechanisms governing the regulation of NCC are not completely understood. Here, through pull-down experiments coupled to mass spectrometry, we found that γ-adducin interacts with the NCC transporter. γ-Adducin colocalized with NCC to the distal convoluted tubule. (22)Na(+) uptake experiments in the Xenopus laevis oocyte showed that γ-adducin… CONTINUE READING

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