γ‐glutamylcysteine ethyl ester‐induced up‐regulation of glutathione protects neurons against Aβ(1–42)‐mediated oxidative stress and neurotoxicity: Implications for Alzheimer's disease

@article{BoydKimball2005glutamylcysteineEE,
  title={$\gamma$‐glutamylcysteine ethyl ester‐induced up‐regulation of glutathione protects neurons against A$\beta$(1–42)‐mediated oxidative stress and neurotoxicity: Implications for Alzheimer's disease},
  author={Debra Boyd-Kimball and Rukhsana Sultana and Hafiz Mohmmad Abdul and David Allan Butterfield},
  journal={Journal of Neuroscience Research},
  year={2005},
  volume={79}
}
Glutathione (GSH) is an important endogenous antioxidant found in millimolar concentrations in the brain. GSH levels have been shown to decrease with aging. Alzheimer's disease (AD) is a neurodegenerative disorder associated with aging and oxidative stress. Aβ(1–42) has been shown to induce oxidative stress and has been proposed to play a central role in the oxidative damage detected in AD brain. It has been shown that administration of γ‐glutamylcysteine ethyl ester (GCEE) increases cellular… 
γ‐Glutamylcysteine ethyl ester protection of proteins from Aβ(1–42)‐mediated oxidative stress in neuronal cell culture: A proteomics approach
TLDR
Proteomic identification of two proteins found to be oxidized significantly in neuronal cultures treated with Aβ(1–42) are reported and pretreatment of neuronal cultures with γ‐glutamylcysteine ethyl ester, a compound that supplies the limiting substrate for the synthesis of glutathione and results in the upregulation of glutATHione in neuronal Cultures, protects both proteins against A β(1-42)‐mediated protein oxidation.
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