γ‐Secretase‐dependent cleavage of amyloid precursor protein regulates osteoblast behavior

@article{McLeod2009SecretasedependentCO,
  title={$\gamma$‐Secretase‐dependent cleavage of amyloid precursor protein regulates osteoblast behavior},
  author={Jane McLeod and Neil Curtis and Huw D. Lewis and Mark A. Good and Michael J. Fagan and Paul G Genever},
  journal={The FASEB Journal},
  year={2009},
  volume={23},
  pages={2942 - 2955}
}
γ‐Secretase cleaves amyloid precursor protein (APP) to generate amyloid‐β (Aβ) peptides, which aggregate in the brain in Alzheimer's disease (AD). γ‐Secretase also cleaves molecules that regulate osteoblast activity, such as Notch and ephrinB2. However, the role of APP in bone is unknown. In this study, the expression, cleavage, and function of APP were investigated during osteogenesis in vitro and in vivo. Expression of all γ‐secretase subunits was confirmed in human primary osteoprogenitors… 
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