γ‐Hydroxybutyric Acid–Induced Cognitive Deficits in the Female Adolescent Rat

@article{Sircar2008HydroxybutyricAC,
  title={$\gamma$‐Hydroxybutyric Acid–Induced Cognitive Deficits in the Female Adolescent Rat},
  author={Ratna Sircar and Ashim Kumar Basak and Debashish Sircar},
  journal={Annals of the New York Academy of Sciences},
  year={2008},
  volume={1139}
}
γ‐hydroxybutyric acid (GHB), a “club drug,” is abused for its euphoric, sedative, and anabolic effects. GHB use and abuse is most prevalent among adolescents and young adults. Most GHB users report amnesia. In the present study, we tested the hypothesis that GHB treatment in female adolescent rats causes deficits in spatial learning and memory. Adolescent female rats were treated daily with GHB (100 mg/kg) for 5 consecutive days. Control rats received isovolumetric saline. Experimental and… 

Effects of γ-hydroxybutyric acid on spatial learning and memory in adolescent and adult female rats

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