γ‐Aminobutyric AcidA Receptor α5‐Subunit Creates Novel Type II Benzodiazepine Receptor Pharmacology

@article{Pritchett1990AminobutyricAR,
  title={$\gamma$‐Aminobutyric AcidA Receptor $\alpha$5‐Subunit Creates Novel Type II Benzodiazepine Receptor Pharmacology},
  author={D. B. Pritchett and P. Seeburg},
  journal={Journal of Neurochemistry},
  year={1990},
  volume={54}
}
Abstract: A cDNA encoding a protein with 70% amino acid identity to the previously characterized γ‐aminobutyric acidA (GABAA receptor α‐subunits was isolated from a rat brain cDNA library by homology screening. As observed for α1‐, α2‐, and α3‐subunits, coexpression of this new α‐subunit (α5) with a β‐ and γ2‐subunit in cultured cells produces receptors displaying high‐affinity binding sites for both muscimol, a GABA agonist, and benzodiazepines. Characteristic of GABAA/benzodiazepine type II… Expand
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