γ‐Aminobutyric Acid Outside the Mammalian Brain

@article{Erd1990AminobutyricAO,
  title={$\gamma$‐Aminobutyric Acid Outside the Mammalian Brain},
  author={S. Erd{\"o} and J. Wolff},
  journal={Journal of Neurochemistry},
  year={1990},
  volume={54}
}
Article de synthese sur le role du GABA en dehors du systeme nerveux central chez les mammiferes: role dans le systeme nerveux peripherique, aspects biochimiques, biologiques morphologiques et fonctionnels 
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References

SHOWING 1-10 OF 201 REFERENCES
Elevated levels of gamma amino butyric acid (GABA) in the thymus gland during the immune response.
TLDR
The present results reveal that the inhibitory neurotransmitter, gamma amino butyric acid is also present in the mouse thymus and that it is significantly elevated following challenge with a T-cell dependent antigen. Expand
γ‐AMINOBUTYRIC ACID RECEPTOR ON VASCULAR SMOOTH MUSCLE OF DOG CEREBRAL ARTERIES
TLDR
γ‐Aminobutyric acid (GABA) had a relaxant effect on dog cerebral arteries which was blocked only by picrotoxin, a known antagonist of GABA receptors, suggesting the existence of GABA receptor receptors in the vascular smooth muscle of dog cerebral artery. Expand
gamma-Aminobutyric acid in peripheral tissues.
TLDR
The identification of GABA in the autonomic nervous system has paved the way for new approaches in pharmacological investigations and the possible functional role ofGABA in neuronal and non-neuronal tissues is discussed. Expand
GABA in the PNS: Demonstration in enteric neurons
TLDR
GABA-immunoreactive neurons survived for over a week in vitro; therefore, they must be intrinsic to the bowel and indicate that GABA is a peripheral (enteric) as well as a central neurotransmitter. Expand
Immunohistochemical studies of the GABA system in the pancreas.
TLDR
Results provide morphological evidence of the coexistence of GABA and insulin in the beta-cells of the endocrine pancreas in rats treated with streptozotocin or alloxan. Expand
Peripheral GABAergic mechanisms
TLDR
Sandor L. Erdo summarizes the current knowledge of GABAergic systems in peripheral tissues and emphasizes the functional relevance of GABA in a series of peripheral organs. Expand
γ-aminobutyric acid enables synaptogenesis in the intact superior cervical ganglion of the adult rat
Local gamma-aminobutyric acid (GABA) application into the intact superior cervical ganglion (SCG) of the adult rat allows active innervation of a surgically implanted hypoglossal nerve in addition toExpand
Gamma-aminobutyric acid, its related enzymes and receptor-binding sites in the human ovary and fallopian tube.
TLDR
Findings indicate some gestation-related role for the ovarian and tubal GABA systems in humans and most GABAergic markers altered significantly in organs from pregnant women. Expand
Specific, vascular localization of GABA-transaminase in the guinea pig lung
TLDR
These findings indicate that the GABA-T activity in the lung is specifically located in blood vessels, and this study is the first to demonstrate GABA- T activity in peripheral blood vessels. Expand
Gestational changes of GABA levels and GABA binding in the human uterus.
TLDR
Some gestation-related functional role for the GABA system in the human uterus is suggested by examined uterine tissue pieces obtained surgically from pregnant and non-pregnant women. Expand
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