γ‐Aminobutyric Acid Outside the Mammalian Brain

@article{Erd1990AminobutyricAO,
  title={$\gamma$‐Aminobutyric Acid Outside the Mammalian Brain},
  author={S. Erd{\"o} and J. Wolff},
  journal={Journal of Neurochemistry},
  year={1990},
  volume={54}
}
Article de synthese sur le role du GABA en dehors du systeme nerveux central chez les mammiferes: role dans le systeme nerveux peripherique, aspects biochimiques, biologiques morphologiques et fonctionnels 
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249 Citations
Highly Influential Citations
3
Background Citations
55
Methods Citations
2
Results Citations
2

249 Citations

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Citation Type

Modern conception on metabolism of γ-aminobutyric acid in the brain
TLDR
The important role of the compartmental distribution of GABA metabolizing enzymes and the glutamate/GABA-glutamine cycle in the regulation of energy state and neuronal activity is discussed. Expand
Identification of γ-aminobutyric acid receptor subunit types in human and rat liver
TLDR
This work documented specific GABA binding to isolated rat hepatocytes in a previous study, and confirmed that GABA binds to heterooligomeric receptors in the mammalian brain and acts as an inhibitory neurotransmitter to drive cell reprograming in mice. Expand
Glutamate Decarboxylase, GABA and Autoimmunity
GABA is a widely utilized neurotransmitter throughout the central and peripheral nervous systems (reviewed in 1–4). Its synthesis is largely controlled by the activity of glutamate decarboxylase… Expand
Proliferative effects of γ‐aminobutyric acid on the gastric cancer cell line are associated with extracellular signal‐regulated kinase 1/2 activation
TLDR
The effects of GABA on the proliferation of a gastric cancer cell line, KATO III, is investigated and it is reported that GABA participates in chondrocyte proliferation. Expand
The Neurotransmitter γ-Aminobutyric Acid Is an Inhibitory Regulator for the Migration of SW 480 Colon Carcinoma Cells
TLDR
GABA reduced the norepinephrine-induced migratory activity of cells within a three-dimensional collagen matrix to spontaneous migration levels, opening new possibilities for pharmacological agonists in cancer therapy. Expand
GABA signalling during development: new data and old questions
TLDR
Recent results on the ontogeny of the different components of embryonic GABA signalling with an emphasis on the synthesis of GABA by different molecular forms of glutamic acid decarboxylase (GAD) are summarized. Expand
Advances in Brief The Neurotransmitter-Aminobutyric Acid Is an Inhibitory Regulator for the Migration of SW 480 Colon Carcinoma Cells 1
-Aminobutyric acid (GABA) is the inhibitory neurotransmitter in the brain, also playing a role in diseases like epilepsy. We now show that this inhibitory neurotransmitter can also reduce migratory… Expand
The structural and functional heterogeneity of glutamic acid decarboxylase: A review
TLDR
Studies of the GABA-synthetic enzyme glutamate decarboxylase have demonstrated the structural and functional heterogeneity of brain GAD, and at least part of this heterogeneity derives from the existence of two GAD genes. Expand
GABA and Endocrine Cells of the Gastro-entero-pancreatic System: A Review
TLDR
GABA has also been involved in the regulation of hormonal secretion in the gastro-entero-pancreatic (GEP) system, but its precise localization and mechanisms of action remain unclear. Expand
Inhibitory role for GABA in autoimmune inflammation
TLDR
It is demonstrated that immune cells synthesize GABA and have the machinery for GABA catabolism, and GABA itself may function as a paracrine or autocrine factor in the immune system. Expand
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