γ‐Aminobutyric Acid Outside the Mammalian Brain

@article{Erd1990AminobutyricAO,
  title={$\gamma$‐Aminobutyric Acid Outside the Mammalian Brain},
  author={S{\'a}ndor L. Erd{\"o} and Joachim R. Wolff},
  journal={Journal of Neurochemistry},
  year={1990},
  volume={54}
}
Article de synthese sur le role du GABA en dehors du systeme nerveux central chez les mammiferes: role dans le systeme nerveux peripherique, aspects biochimiques, biologiques morphologiques et fonctionnels 
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258 Citations
Highly Influential Citations
3
Background Citations
54
Methods Citations
2
Results Citations
2

258 Citations

Modern conception on metabolism of γ-aminobutyric acid in the brain
TLDR
The important role of the compartmental distribution of GABA metabolizing enzymes and the glutamate/GABA-glutamine cycle in the regulation of energy state and neuronal activity is discussed.
Glutamate Decarboxylase, GABA and Autoimmunity
TLDR
GAD and GABA have been associated with a number of neurogenetic diseases and pharmacological interference with GAD or GABA rapidly induces seizures in both man and animals.
Proliferative effects of γ‐aminobutyric acid on the gastric cancer cell line are associated with extracellular signal‐regulated kinase 1/2 activation
TLDR
The effects of GABA on the proliferation of a gastric cancer cell line, KATO III, is investigated and it is reported that GABA participates in chondrocyte proliferation.
The Neurotransmitter γ-Aminobutyric Acid Is an Inhibitory Regulator for the Migration of SW 480 Colon Carcinoma Cells
TLDR
GABA reduced the norepinephrine-induced migratory activity of cells within a three-dimensional collagen matrix to spontaneous migration levels, opening new possibilities for pharmacological agonists in cancer therapy.
GABA signalling during development: new data and old questions
TLDR
Recent results on the ontogeny of the different components of embryonic GABA signalling with an emphasis on the synthesis of GABA by different molecular forms of glutamic acid decarboxylase (GAD) are summarized.
The structural and functional heterogeneity of glutamic acid decarboxylase: A review
TLDR
Studies of the GABA-synthetic enzyme glutamate decarboxylase have demonstrated the structural and functional heterogeneity of brain GAD, and at least part of this heterogeneity derives from the existence of two GAD genes.
Emerging Roles of γ Aminobutyric Acid (GABA) Gated Channels in Plant Stress Tolerance
TLDR
The role of GABA in plant growth and development under abiotic stress, its interactions with other signaling molecules and the probability that there are other anion channels with important roles in stress tolerance that are gated by GABA are explored.
GABA and Endocrine Cells of the Gastro-entero-pancreatic System: A Review
TLDR
GABA has also been involved in the regulation of hormonal secretion in the gastro-entero-pancreatic (GEP) system, but its precise localization and mechanisms of action remain unclear.
Non-Neuronal GABA Systems: An Overview
TLDR
This chapter is, therefore, an attempt to summarize the recent knowledge of non-neuronal GABA systems in mammals and to emphasize that GABA may play a specific mediator role in a number ofNon-NEuronal tissues.
γ‐Amino‐butyric acid immunoreactivity in intramucosal colonic tumors
TLDR
This work examined the expression of GABA in intramucosal colonic tumors to clarify the relation between GABA and the degree of atypia and suggests that GABA plays a role in the proliferation or maturation of some types of cells.
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References

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TLDR
γ‐Aminobutyric acid (GABA) had a relaxant effect on dog cerebral arteries which was blocked only by picrotoxin, a known antagonist of GABA receptors, suggesting the existence of GABA receptor receptors in the vascular smooth muscle of dog cerebral artery.
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TLDR
Evidence is presented that GABA may also be a neurotransmitter in the vertebrate peripheral autonomie nervous system and levels of endogenous GABA in strips of taenia coli containing the myenteric plexus are measured.
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