γ‐Aminobutyric Acid Outside the Mammalian Brain

@article{Erd1990AminobutyricAO,
  title={$\gamma$‐Aminobutyric Acid Outside the Mammalian Brain},
  author={S{\'a}ndor L. Erd{\"o} and Joachim R. Wolff},
  journal={Journal of Neurochemistry},
  year={1990},
  volume={54}
}
Article de synthese sur le role du GABA en dehors du systeme nerveux central chez les mammiferes: role dans le systeme nerveux peripherique, aspects biochimiques, biologiques morphologiques et fonctionnels 
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250 Citations
Highly Influential Citations
3
Background Citations
54
Methods Citations
2
Results Citations
2

250 Citations

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Citation Type

Modern conception on metabolism of γ-aminobutyric acid in the brain
TLDR
The important role of the compartmental distribution of GABA metabolizing enzymes and the glutamate/GABA-glutamine cycle in the regulation of energy state and neuronal activity is discussed. Expand
Identification of γ-aminobutyric acid receptor subunit types in human and rat liver
TLDR
This work documented specific GABA binding to isolated rat hepatocytes in a previous study, and confirmed that GABA binds to heterooligomeric receptors in the mammalian brain and acts as an inhibitory neurotransmitter to drive cell reprograming in mice. Expand
Glutamate Decarboxylase, GABA and Autoimmunity
GABA is a widely utilized neurotransmitter throughout the central and peripheral nervous systems (reviewed in 1–4). Its synthesis is largely controlled by the activity of glutamate decarboxylase… Expand
Proliferative effects of γ‐aminobutyric acid on the gastric cancer cell line are associated with extracellular signal‐regulated kinase 1/2 activation
TLDR
The effects of GABA on the proliferation of a gastric cancer cell line, KATO III, is investigated and it is reported that GABA participates in chondrocyte proliferation. Expand
The Neurotransmitter γ-Aminobutyric Acid Is an Inhibitory Regulator for the Migration of SW 480 Colon Carcinoma Cells
TLDR
GABA reduced the norepinephrine-induced migratory activity of cells within a three-dimensional collagen matrix to spontaneous migration levels, opening new possibilities for pharmacological agonists in cancer therapy. Expand
GABA signalling during development: new data and old questions
TLDR
Recent results on the ontogeny of the different components of embryonic GABA signalling with an emphasis on the synthesis of GABA by different molecular forms of glutamic acid decarboxylase (GAD) are summarized. Expand
Advances in Brief The Neurotransmitter-Aminobutyric Acid Is an Inhibitory Regulator for the Migration of SW 480 Colon Carcinoma Cells 1
-Aminobutyric acid (GABA) is the inhibitory neurotransmitter in the brain, also playing a role in diseases like epilepsy. We now show that this inhibitory neurotransmitter can also reduce migratory… Expand
The structural and functional heterogeneity of glutamic acid decarboxylase: A review
TLDR
Studies of the GABA-synthetic enzyme glutamate decarboxylase have demonstrated the structural and functional heterogeneity of brain GAD, and at least part of this heterogeneity derives from the existence of two GAD genes. Expand
GABA and Endocrine Cells of the Gastro-entero-pancreatic System: A Review
TLDR
GABA has also been involved in the regulation of hormonal secretion in the gastro-entero-pancreatic (GEP) system, but its precise localization and mechanisms of action remain unclear. Expand
Inhibitory role for GABA in autoimmune inflammation
TLDR
It is demonstrated that immune cells synthesize GABA and have the machinery for GABA catabolism, and GABA itself may function as a paracrine or autocrine factor in the immune system. Expand
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References

SHOWING 1-10 OF 201 REFERENCES
Elevated levels of gamma amino butyric acid (GABA) in the thymus gland during the immune response.
TLDR
The present results reveal that the inhibitory neurotransmitter, gamma amino butyric acid is also present in the mouse thymus and that it is significantly elevated following challenge with a T-cell dependent antigen. Expand
γ‐AMINOBUTYRIC ACID RECEPTOR ON VASCULAR SMOOTH MUSCLE OF DOG CEREBRAL ARTERIES
TLDR
γ‐Aminobutyric acid (GABA) had a relaxant effect on dog cerebral arteries which was blocked only by picrotoxin, a known antagonist of GABA receptors, suggesting the existence of GABA receptor receptors in the vascular smooth muscle of dog cerebral artery. Expand
gamma-Aminobutyric acid in peripheral tissues.
TLDR
The identification of GABA in the autonomic nervous system has paved the way for new approaches in pharmacological investigations and the possible functional role ofGABA in neuronal and non-neuronal tissues is discussed. Expand
GABA in the PNS: Demonstration in enteric neurons
TLDR
GABA-immunoreactive neurons survived for over a week in vitro; therefore, they must be intrinsic to the bowel and indicate that GABA is a peripheral (enteric) as well as a central neurotransmitter. Expand
Immunohistochemical studies of the GABA system in the pancreas.
TLDR
Results provide morphological evidence of the coexistence of GABA and insulin in the beta-cells of the endocrine pancreas in rats treated with streptozotocin or alloxan. Expand
Peripheral GABAergic mechanisms
TLDR
Sandor L. Erdo summarizes the current knowledge of GABAergic systems in peripheral tissues and emphasizes the functional relevance of GABA in a series of peripheral organs. Expand
γ-aminobutyric acid enables synaptogenesis in the intact superior cervical ganglion of the adult rat
Local gamma-aminobutyric acid (GABA) application into the intact superior cervical ganglion (SCG) of the adult rat allows active innervation of a surgically implanted hypoglossal nerve in addition to… Expand
Gamma-aminobutyric acid, its related enzymes and receptor-binding sites in the human ovary and fallopian tube.
TLDR
Findings indicate some gestation-related role for the ovarian and tubal GABA systems in humans and most GABAergic markers altered significantly in organs from pregnant women. Expand
Specific, vascular localization of GABA-transaminase in the guinea pig lung
TLDR
These findings indicate that the GABA-T activity in the lung is specifically located in blood vessels, and this study is the first to demonstrate GABA- T activity in peripheral blood vessels. Expand
Gestational changes of GABA levels and GABA binding in the human uterus.
TLDR
Some gestation-related functional role for the GABA system in the human uterus is suggested by examined uterine tissue pieces obtained surgically from pregnant and non-pregnant women. Expand
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