γ‐Aminobutyric Acid Outside the Mammalian Brain

@article{Erd1990AminobutyricAO,
  title={$\gamma$‐Aminobutyric Acid Outside the Mammalian Brain},
  author={S{\'a}ndor L. Erd{\"o} and Joachim R. Wolff},
  journal={Journal of Neurochemistry},
  year={1990},
  volume={54}
}
Article de synthese sur le role du GABA en dehors du systeme nerveux central chez les mammiferes: role dans le systeme nerveux peripherique, aspects biochimiques, biologiques morphologiques et fonctionnels 
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References

SHOWING 1-10 OF 201 REFERENCES
γ‐AMINOBUTYRIC ACID RECEPTOR ON VASCULAR SMOOTH MUSCLE OF DOG CEREBRAL ARTERIES
TLDR
γ‐Aminobutyric acid (GABA) had a relaxant effect on dog cerebral arteries which was blocked only by picrotoxin, a known antagonist of GABA receptors, suggesting the existence of GABA receptor receptors in the vascular smooth muscle of dog cerebral artery.
Immunohistochemical studies of the GABA system in the pancreas.
TLDR
Results provide morphological evidence of the coexistence of GABA and insulin in the beta-cells of the endocrine pancreas in rats treated with streptozotocin or alloxan.
GABA may be a neurotransmitter in the vertebrate peripheral nervous system
TLDR
Evidence is presented that GABA may also be a neurotransmitter in the vertebrate peripheral autonomie nervous system and levels of endogenous GABA in strips of taenia coli containing the myenteric plexus are measured.
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