βig-h3 potentiates the profibrogenic effect of TGFβ signaling on connective tissue progenitor cells through the negative regulation of master chondrogenic genes.

@article{LordaDiez2013igh3PT,
  title={βig-h3 potentiates the profibrogenic effect of TGFβ signaling on connective tissue progenitor cells through the negative regulation of master chondrogenic genes.},
  author={Carlos I. Lorda-Diez and Juan A Montero and Manuel J. Diaz-Mendoza and Juan Antonio Garcia-Porrero and Juan M Hurle},
  journal={Tissue engineering. Part A},
  year={2013},
  volume={19 3-4},
  pages={448-57}
}
Tendons and cartilage are specialized forms of connective tissues originated from common progenitor cells. Initial stages of differentiation of these tissues are characterized by the formation of cell aggregates, which share many molecular markers. Once differentiated, these cells retain considerable plasticity, and chondral metaplasia of tendon and fibrous connective tissues and eventual ossification often accompany degenerative diseases in the adult musculoskeletal system. While this fact is… CONTINUE READING