βIV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier

@article{Komada2002IVspectrinRS,
  title={βIV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier},
  author={Masayuki Komada and Philippe Soriano},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={156},
  pages={337 - 348}
}
beta-Spectrin and ankyrin are major components of the membrane cytoskeleton. We have generated mice carrying a null mutation in the betaIV-spectrin gene using gene trapping in embryonic stem cells. Mice homozygous for the mutation exhibit tremors and contraction of hindlimbs. betaIV-spectrin expression is mostly restricted to neurons, where it colocalizes with and binds to ankyrin-G at axon initial segments (AISs) and nodes of Ranvier (NR). In betaIV-spectrin-null neurons, neither ankyrin-G nor… CONTINUE READING
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