βIII-Tubulin: biomarker of taxane resistance or drug target?

@article{Karki2013IIITubulinBO,
  title={βIII-Tubulin: biomarker of taxane resistance or drug target?},
  author={Roshan Karki and Marisa Mariani and Mirko Andreoli and Shiquan He and Giovanni Scambia and Shohreh Shahabi and Cristiano Ferlini},
  journal={Expert opinion on therapeutic targets},
  year={2013},
  volume={17 4},
  pages={461-72}
}
INTRODUCTION βIII-Tubulin (TUBB3) is predominantly expressed in neurons of the central and peripheral nervous systems, while in normal non-neoplastic tissues it is barely detectable. By contrast, this cytoskeletal protein is abundant in a wide range of tumors. βIII-Tubulin is linked to dynamic instability of microtubules (MTs), weakening the effects of agents interfering with MT polymerization. Based on this principle, early studies introduced the classical theory linking βIII-tubulin with a… CONTINUE READING
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