β3 integrin–mediated spreading induced by matrix-bound BMP-2 controls Smad signaling in a stiffness-independent manner

@article{Fourel20163IS,
  title={$\beta$3 integrin–mediated spreading induced by matrix-bound BMP-2 controls Smad signaling in a stiffness-independent manner},
  author={L. Fourel and A. Valat and E. Faurobert and R. Guillot and Ingrid Bourrin-Reynard and K. Ren and L. Lafanech{\`e}re and E. Planus and C. Picart and C. Albig{\`e}s-Rizo},
  journal={The Journal of Cell Biology},
  year={2016},
  volume={212},
  pages={693 - 706}
}
Matrix-bound BMP-2 is sufficient to induce β3 integrin–dependent, Cdc42/Src/FAK/ILK-mediated cell spreading by overriding the stiffness response through actin and adhesion site dynamics, showing BMP receptors and integrins work together to control signaling and tensional homeostasis, thereby coupling cell adhesion and fate commitment. 
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