β3 adrenergic receptor selective stimulation during ischemia/reperfusion improves cardiac function in translational models through inhibition of mPTP opening in cardiomyocytes

@article{GarcaPrieto20143AR,
  title={β3 adrenergic receptor selective stimulation during ischemia/reperfusion improves cardiac function in translational models through inhibition of mPTP opening in cardiomyocytes},
  author={Jaime Garc{\'i}a-Prieto and Jos{\'e} Manuel Garc{\'i}a-Ru{\'i}z and David Sanz-Rosa and Andr{\'e}s Pun and Ana Cristina Garc{\'i}a-{\'A}lvarez and Sean M. Davidson and Leticia Fern{\'a}ndez-Friera and Mario Nuno-Ayala and Rodrigo Fern{\'a}ndez-Jim{\'e}nez and Juan A. Bernal and Jos{\'e} Luis Izquierdo-Garcia and Jes{\'u}s Jimenez-Borreguero and Gonzalo E. Pizarro and Jes{\'u}s Ruiz-Cabello and Carlos Macaya and Valentin Fuster and Derek M. Yellon and Borja Guarch Ib{\'a}{\~n}ez},
  journal={Basic Research in Cardiology},
  year={2014},
  volume={109},
  pages={1-15}
}
Selective stimulation of β3 adrenergic-receptor (β3AR) has been shown to reduce infarct size in a mouse model of myocardial ischemia/reperfusion. However, its functional long-term effect and the cardioprotective mechanisms at the level of cardiomyocytes have not been elucidated, and the impact of β3AR stimulation has not been evaluated in a more translational large animal model. This study aimed at evaluating pre-perfusion administration of BRL37344 both in small and large animal models of… CONTINUE READING

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