β2-microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells.

@article{Josson20112microglobulinIE,
  title={β2-microglobulin induces epithelial to mesenchymal transition and confers cancer lethality and bone metastasis in human cancer cells.},
  author={Sajni Josson and Takeo Nomura and Jen-Tai Lin and Wen-Chin Huang and Daqing Wu and Haiyen E. Zhau and Majd Zayzafoon and Mikhayla Weizmann and Murali Gururajan and Leland W K Chung},
  journal={Cancer research},
  year={2011},
  volume={71 7},
  pages={2600-10}
}
Bone metastasis is one of the predominant causes of cancer lethality. This study demonstrates for the first time how β2-microglobulin (β2-M) supports lethal metastasis in vivo in human prostate, breast, lung, and renal cancer cells. β2-M mediates this process by activating epithelial to mesenchymal transition (EMT) to promote lethal bone and soft tissue metastases in host mice. β2-M interacts with its receptor, hemochromatosis (HFE) protein, to modulate iron responsive pathways in cancer cells… CONTINUE READING
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