β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion

@inproceedings{Creed20152adrenoceptorSR,
  title={β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion},
  author={Sarah J. Creed and Caroline P. Le and Mona Hassan and Cindy K Pon and Sabine Albold and Keefe T. Chan and Matthew E. Berginski and Zhendong Huang and James E Bear and J Robert Lane and Michelle L Halls and Davide Ferrari and Cameron J Nowell and Erica K. Sloan},
  booktitle={Breast Cancer Research},
  year={2015}
}
For efficient metastatic dissemination, tumor cells form invadopodia to degrade and move through three-dimensional extracellular matrix. However, little is known about the conditions that favor invadopodia formation. Here, we investigated the effect of β-adrenoceptor signaling - which allows cells to respond to stress neurotransmitters - on the formation of invadopodia and examined the effect on tumor cell invasion. To characterize the molecular and cellular mechanisms of β-adrenergic signaling… CONTINUE READING
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