β2-adrenergic receptor Thr164Ile polymorphism, obesity, and diabetes: comparison with FTO, MC4R, and TMEM18 polymorphisms in more than 64,000 individuals.

@article{Thomsen20122adrenergicRT,
  title={β2-adrenergic receptor Thr164Ile polymorphism, obesity, and diabetes: comparison with FTO, MC4R, and TMEM18 polymorphisms in more than 64,000 individuals.},
  author={Mette Willumstad Thomsen and Morten Dahl and Anne Tybj{\ae}rg-Hansen and B\orge G. Nordestgaard},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2012},
  volume={97 6},
  pages={E1074-9}
}
CONTEXT The β(2)-adrenergic receptor (ADRB2) influences regulation of energy balance by stimulating catecholamine-induced lipolysis in adipose tissue. The rare functional ADRB2rs1800888(Thr164Ile) polymorphism could therefore influence risk of obesity and subsequently diabetes. OBJECTIVE We tested the hypothesis that the ADRB2rs1800888(Thr164Ile) polymorphism associates with risk of obesity and diabetes and compared effect sizes with those of FTO(rs9939609), MC4R(rs17782313), and TMEM18… CONTINUE READING

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