β2-adrenergic receptor Thr164IIe polymorphism, blood pressure and ischaemic heart disease in 66 750 individuals

@article{Thomsen20122adrenergicRT,
  title={β2-adrenergic receptor Thr164IIe polymorphism, blood pressure and ischaemic heart disease in 66 750 individuals},
  author={Mette Willumstad Thomsen and Morten Dahl and Anne Tybjaerg-Hansen and B\orge G. Nordestgaard},
  journal={Journal of internal medicine},
  year={2012},
  volume={271 3},
  pages={305-14}
}
OBJECTIVES The β(2) -adrenergic receptor (ADRB2) is located on smooth muscle cells and is an important regulator of smooth muscle tone. The Thr164Ile polymorphism (rs1800888) in the ADRB2 gene is rare but has profound functional consequences on receptor function and could cause lifelong elevated smooth muscle tone. We tested the hypothesis that Thr164Ile is associated with increased blood pressure, increased frequency of hypertension and increased risk of cardiovascular disease (CVD… CONTINUE READING

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