β2-Agonist Induced cAMP Is Decreased in Asthmatic Airway Smooth Muscle Due to Increased PDE4D

@inproceedings{Trian20112AgonistIC,
  title={β2-Agonist Induced cAMP Is Decreased in Asthmatic Airway Smooth Muscle Due to Increased PDE4D},
  author={Thomas Trian and Janette K Burgess and Kyoko Niimi and Lyn Margaret Moir and Qi Mu Ge and Patrick Berger and Stephen B. Liggett and J. L. Black and Brian Gregory George Oliver},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND AND OBJECTIVE Asthma is associated with airway narrowing in response to bronchoconstricting stimuli and increased airway smooth muscle (ASM) mass. In addition, some studies have suggested impaired β-agonist induced ASM relaxation in asthmatics, but the mechanism is not known. OBJECTIVE To characterize the potential defect in β-agonist induced cAMP in ASM derived from asthmatic in comparison to non-asthmatic subjects and to investigate its mechanism. METHODS We examined β(2… CONTINUE READING
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