β2-Adrenoreceptors of regulatory lymphocytes are essential for vagal neuromodulation of the innate immune system.

@article{Vida20112AdrenoreceptorsOR,
  title={β2-Adrenoreceptors of regulatory lymphocytes are essential for vagal neuromodulation of the innate immune system.},
  author={Gergely Vida and Geber Pe{\~n}a and Alexandre Kanashiro and Mar{\'i}a Del Roc{\'i}o Thompson-Bonilla and David Christopher Palange and Edwin A. Deitch and L. Fernando Ulloa},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2011},
  volume={25 12},
  pages={4476-85}
}
The nervous system is classically organized into sympathetic and parasympathetic systems acting in opposition to maintain physiological homeostasis. Here, we report that both systems converge in the activation of β2-adrenoceptors of splenic regulatory lymphocytes to control systemic inflammation. Vagus nerve stimulation fails to control serum TNF levels in either β2-knockout or lymphocyte-deficient nude mice. Unlike typical suppressor CD25(+) cells, the transfer of CD4(+)CD25(-) regulatory… CONTINUE READING

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