β2-Adrenoceptor Regulation of CGRP Release from Capsaicin-sensitive Neurons

@article{Bowles20032AdrenoceptorRO,
  title={$\beta$2-Adrenoceptor Regulation of CGRP Release from Capsaicin-sensitive Neurons},
  author={W. Bowles and C. M. Flores and D. Jackson and K. Hargreaves},
  journal={Journal of Dental Research},
  year={2003},
  volume={82},
  pages={308 - 311}
}
Previous studies have suggested that neurotransmitter substances from the sympatho-adrenomedullary system regulate pulpal blood flow (PBF), in part, by the inhibition of vasoactive neuropeptide release from pulpal sensory neurons. However, no study has evaluated the role of β-adrenoceptors. We evaluated the hypothesis that activation of β-adrenoceptors inhibits immunoreactive calcitonin gene-related peptide (iCGRP) release from capsaicin-sensitive nociceptive neurons via in vitro superfusion of… Expand
Adrenergic regulation of capsaicin-sensitive neurons in dental pulp.
TLDR
These studies suggest that adrenergic agonists may reduce postoperative pain in part via a direct inhibition of capsaicin-sensitive nociceptors, which may lead to the development of selective, peripherally acting, adrenergic analgesics. Expand
Activation of Capsaicin-Sensitive Sensory Neurons by Carvedilol, a Nonselective β-Blocker, in Spontaneous Hypertensive Rats
TLDR
It is suggested that the low dose of carvedilol might activate CSSNs in SHR to increase the release of CGRP, thereby decreasing blood pressure with an increase in renal tissue blood flow. Expand
Effect of Sympathetic and Parasympathetic Mediators on the Release of Calcitonin Gene-Related Peptide and Prostaglandin E2 from Rat Dura Mater, in vitro
TLDR
It is concluded that sympathetic transmitters may control nociceptor sensitivity via increased basal PGE2 levels, a possible mechanism to facilitate headache generation. Expand
Tissue pH and Temperature Regulate Pulpal Nociceptors
TLDR
The study indicates that environmental stimuli regulate the activity of capsaicin-sensitive neurons innervating dental pulp, and these factors may be significant clinically in the development and amelioration of dental pain. Expand
The CGRP receptor antagonist BIBN4096 inhibits prolonged meningeal afferent activation evoked by brief local K+ stimulation but not cortical spreading depression-induced afferent sensitization
TLDR
While C GRP-mediated activation of meningeal afferents evoked by cortical efflux of K+ could promote headache, acute activation of CGRP receptors may not play a key role in mediating CSD-evoked headache. Expand
The CGRP receptor antagonist BIBN4096 inhibits prolonged meningeal afferent activation evoked by brief local K+ stimulation but not cortical spreading depression-induced afferent sensitization but not cortical spreading depression-induced afferent sensitization
Abstract Introduction Cortical spreading depression (CSD) is believed to promote migraine headache by enhancing the activity and mechanosensitivity of trigeminal intracranial meningeal afferents. OneExpand
CGRP signaling mediates prolonged meningeal afferent activation evoked by brief local K+ stimulation but not cortical spreading depression-induced afferent sensitization
TLDR
While CGRP-mediated activation of meningeal afferents evoked by cortical efflux of excitatory mediators could promote headache, this mechanism is unlikely to play a key role in mediating the headache of migraine triggered by CSD. Expand
Variability in Capsaicin-stimulated Calcitonin Gene-related Peptide Release from Human Dental Pulp.
TLDR
A within-subject study design improves the variability and maximizes the potential of this powerful translational model to test the efficacy of novel pharmacotherapeutic agents on human peripheral nociceptors. Expand
Regulation of pulpal microcirculation by calcitonin gene-related peptide
TLDR
Investigation of the function of calcitonin gene-related peptide in regulatory mechanism of pulpal microcirculation provided evidences that even though the local vasodilatory function of CGRP are weak, C GRP is effectively involved in blocking the vasoconstriction caused by sympathetic nerve. Expand
Variability in Capsaicin-Stimulated CGRP Release from Human Dental Pulp
Introduction—The unique innervation and anatomical features of the dental pulp contribute to the remarkable finding that any physical stimulation of pulpal tissue is painful. Further, whenExpand
...
1
2
3
4
...

References

SHOWING 1-10 OF 39 REFERENCES
Intrinsic Regulation of CGRP Release by Dental Pulp Sympathetic Fibers
TLDR
Testing the hypothesis that activation of pulpal sympathetic terminals inhibits exocytosis of immunoreactive calcitonin gene-related peptide (iCGRP) from peptidergic afferents innervating bovine dental pulp demonstrates that norepinephrine inhibits capsaicin-evoked iC GRP release. Expand
β2-Adrenoceptor-Mediated Prejunctional Facilitation and Postjunctional Inhibition of Sympathetic Neuroeffector Transmission in the Guinea Pig Vas Deferens
This study examines the role of prejunctional and postjunctional β-adrenoceptors in the modulation of sympathetic cotransmission in the guinea pig vas deferens. The prejunctional involvement ofExpand
Pharmacology of noradrenaline and neuropeptide tyrosine (NPY)‐mediated sympathetic cotransmission
TLDR
A complex interplay seems to occur at both the pre‐ and postjunctional levels of transmission for the classical transmitter NA and the coexisting peptide NPY, creating a great diversity of chemical signalling potential. Expand
Beta2-adrenoceptor-mediated prejunctional facilitation and postjunctional inhibition of sympathetic neuroeffector transmission in the guinea pig vas deferens.
TLDR
Results demonstrate that beta2-adrenoceptors can influence sympathetic neuroeffector transmission both prejunctionally and postjunctional, where they facilitate equally well the release of sympathetic cotransmitters and postJunctionally,Where they inhibit smooth muscle contractions evoked by ATP. Expand
Modulation by presynaptic β-adrenoceptors of noradrenaline release from sympathetic nerves in human dental pulp
TLDR
The results establish the presence of presynaptic β -adrenoceptors on sympathetic nerves in human dental pulp and it is suggested that they are of the β 2 -subtype, although a greater range of agonists and antagonists needs to be used to clarify the nature of theβ -ad Renoceptor subtype. Expand
Modulation by presynaptic beta-adrenoceptors of noradrenaline release from sympathetic nerves in human dental pulp.
TLDR
The results establish the presence of presynaptic beta-adrenoceptors on sympathetic nerves in human dental pulp and it is suggested that they are of the beta2-subtype, although a greater range of agonists and antagonists needs to be used to clarify the nature of the the beta- adrenoceptor subtype. Expand
Epinephrine produces a beta-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors.
TLDR
Consistent with the hypothesis that epinephrine produces hyperalgesia by a direct action on primary afferent nociceptors, it was found to sensitize small-diameter dorsal root ganglion neurons in culture and cause a potentiation of tetrodotoxin-resistant sodium current. Expand
Implication of β1- and β2-adrenergic receptors in the antinociceptive effect of tricyclic antidepressants
Abstract Tricyclic antidepressants have been shown to be useful for the treatment of pain of varying etiology. Monoaminergic systems seem to be implicated in this phenomenon. In this study, theExpand
Ectopic alpha2-adrenoceptors couple to N-type Ca2+ channels in axotomized rat sensory neurons.
  • F. Abdulla, P. Smith
  • Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1997
TLDR
The strongest effects of noradrenaline were seen in small cells and in cells from animals that exhibited autotomy, a self-mutilatory behavior that can accompany peripheral nerve damage. Expand
Ectopic α2-Adrenoceptors Couple to N-Type Ca2+ Channels in Axotomized Rat Sensory Neurons
TLDR
The strongest effects of noradrenaline were seen in small cells and in cells from animals that exhibited autotomy, a self-mutilatory behavior that can accompany peripheral nerve damage. Expand
...
1
2
3
4
...