β2-Adrenoceptor Involved in Smoking-Induced Airway Mucus Hypersecretion through β-Arrestin-Dependent Signaling

@inproceedings{Zhou20142AdrenoceptorII,
  title={β2-Adrenoceptor Involved in Smoking-Induced Airway Mucus Hypersecretion through β-Arrestin-Dependent Signaling},
  author={Yujiao Zhou and Yuan Zhang and Yang Guo and Y Jonathan Zhang and Ming Xu and Bei He},
  booktitle={PloS one},
  year={2014}
}
Progression of chronic obstructive pulmonary disease is associated with small airway obstruction by accumulation of inflammatory mucous exudates. However, the mechanism of mucin hypersecretion after exposure to cigarette smoke (CS) is still not clear. In this study, we explored the contribution of β2-adrenoceptor (β2-AR) signaling to CS extract (CSE)-induced mucus hypersecretion in vitro and examined the effect of a β-blocker on airway mucin hypersecretion in vivo. NCI-H292 epithelial cell line… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 51 references

Effects of long-term treatment with propranolol on the relaxation function of trachea isolated from rats exposed to cigarette smoke

  • Y Guo, Y Zhang, N Shen, Y Zhou
  • Ihalation Toxicology,
  • 2014
1 Excerpt

Similar Papers

Loading similar papers…