β2-Adrenergic receptor signaling in osteoblasts contributes to the catabolic effect of glucocorticoids on bone.

@article{Ma20112AdrenergicRS,
  title={β2-Adrenergic receptor signaling in osteoblasts contributes to the catabolic effect of glucocorticoids on bone.},
  author={Yun Ma and Jeffry S Nyman and Huan Tao and Heather H Moss and Xiangli Yang and Florent Elefteriou},
  journal={Endocrinology},
  year={2011},
  volume={152 4},
  pages={
          1412-22
        }
}
The sympathetic nervous system is a physiological regulator of bone homeostasis. Autonomic nerves are indeed present in bone, bone cells express the β2-adrenergic receptors (β2AR), and pharmacological or genetic disruption of sympathetic outflow to bone induces bone gain in rodents. These recent findings implied that conditions that affect β2AR signaling in osteoblasts and/or sympathetic drive to bone may contribute to bone diseases. In this study, we show that dexamethasone stimulates the… CONTINUE READING