β1 integrin-dependent Rac/group I PAK signaling mediates YAP activation of Yes-associated protein 1 (YAP1) via NF2/merlin.

@article{Sabra20171IR,
  title={β1 integrin-dependent Rac/group I PAK signaling mediates YAP activation of Yes-associated protein 1 (YAP1) via NF2/merlin.},
  author={Hiba Sabra and Molly Brunner and Vinay Mandati and Bernhard Wehrle-Haller and Dominique Lallemand and Anne-Sophie Ribba and Genevi{\`e}ve Chevalier and Philippe Guardiola and Marc R. Block and Daniel Bouvard},
  journal={The Journal of biological chemistry},
  year={2017},
  volume={292 47},
  pages={
          19179-19197
        }
}
Cell adhesion to the extracellular matrix or to surrounding cells plays a key role in cell proliferation and differentiation and is critical for proper tissue homeostasis. An important pathway in adhesion-dependent cell proliferation is the Hippo signaling cascade, which is coregulated by the transcription factors Yes-associated protein 1 (YAP1) and transcriptional coactivator with PDZ-binding motif (TAZ). However, how cells integrate extracellular information at the molecular level to regulate… CONTINUE READING
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