β1-Adrenoceptor gene variations: a role in idiopathic dilated cardiomyopathy?

@article{Podlowski20001AdrenoceptorGV,
  title={$\beta$1-Adrenoceptor gene variations: a role in idiopathic dilated cardiomyopathy?},
  author={Svenia Podlowski and Katrin Wenzel and Hans Peter Luther and Johannes M{\"u}ller and Peter Bramlage and Gert Baumann and Stephan B. Felix and Astrid Speer and Roland Hetzer and Karla K{\"o}pke and Margret R. Hoehe and Gerd Wallukat},
  journal={Journal of Molecular Medicine},
  year={2000},
  volume={78},
  pages={87-93}
}
Abstract.A substantial body of evidence suggests involvement of the human β1-adrenoceptor (β1-AR) gene in the pathophysiology of dilated cardiomyopathy (DCM), a severe heart disease of significant public health impact. β1-AR-mediated signal transduction is dramatically altered due to downregulation, resulting in an impairment of myocardial response. The important role of genetic factors in idiopathic dilated cardiomyopathy (IDCM) recently recognized, we analyzed this prime candidate gene for… 
Suppressive effect of the Gly389 allele of the beta1-adrenergic receptor gene on the occurrence of ventricular tachycardia in dilated cardiomyopathy.
  • C. Iwai, H. Akita, M. Yokoyama
  • Biology, Medicine
    Circulation journal : official journal of the Japanese Circulation Society
  • 2002
TLDR
The Gly389 variant supressed the occurrence of VT in DCM, suggesting that this allele confers a decreased risk of sudden death.
The Emerging Pharmacogenomics of the β-Adrenergic Receptors
TLDR
The current state of knowledge and understanding of the genetic variation present in the three human β-adrenergic receptor genes is reviewed to provide a foundation for the development of novel pharmacologic approaches where selection of and dosing of cardiovascular therapy is tailored to individuals on the basis of each patient's specific genetic makeup.
The functional significance of genetic variation within the beta-adrenoceptor.
TLDR
The data on the in vitro behaviour of these two receptor variants is reviewed here, along with the evidence that they may affect both the risk of cardiovascular disease and the therapeutic response to beta-1 adrenoceptor antagonists.
Pharmacogenetics of ò1-Adrenergic Receptor Blockers in Heart FailureTherapy: A Systematic Review
TLDR
The findings of the current study have shown that β1-AR polymorphisms have an effect on survival and improvement in left ventricular ejection fraction in HF patients who were Arg389 homozygotes carriers treated with metoprolol and bucindolol.
β-Adrenergic Receptor Polymorphisms: Cardiovascular Disease Associations and Pharmacogenetics
TLDR
In vitro functional studies suggest that these polymorphisms in both the β1AR and β2AR genes have functional significance and the relevance of single polymorphism vs. haplotype analysis is discussed.
Adrenergic receptor polymorphisms and cardiac function (and dysfunction): a failure to communicate?
TLDR
In patients with congestive heart failure, polymorphisms of both β1- and β2-adrenergic receptors have been linked with disease expression, and the importance of the current findings from Brodde and colleagues in this issue of Circulation is importance.
Mutations in the beta1 adrenergic receptor gene and massive obesity in Japanese.
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TLDR
The genomic organization of β 1 -adrenoceptor is described here for the first time and a unique and frequent polymorphism is found in the coding sequence of the gene which predicts an Arg389Gly substitution.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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