β1-Adrenergic receptor blockade extends the life span of Drosophila and long-lived mice

@article{Spindler20121AdrenergicRB,
  title={β1-Adrenergic receptor blockade extends the life span of Drosophila and long-lived mice},
  author={Stephen Richard Spindler and Patricia L. Mote and Rui Li and Joseph Dhahbi and Amy Yamakawa and James M. Flegal and Daniel R Jeske and Alex L. Lublin},
  journal={AGE},
  year={2012},
  volume={35},
  pages={2099-2109}
}
Chronic treatment with β-adrenergic receptor (βAR) agonists increases mortality and morbidity while βAR antagonists (β-blockers) decrease all-cause mortality for those at risk of cardiac disease. Levels of sympathetic nervous system βAR agonists and βAR activity increase with age, and this increase may hasten the development of age-related mortality. Here, we show that β-blockers extend the life span of healthy metazoans. The β-blockers metoprolol and nebivolol, administered in food daily… CONTINUE READING
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