β1 Adrenergic Receptor Polymorphisms and Heart Failure: A Meta-Analysis on Susceptibility, Response to β-Blocker Therapy and Prognosis

@inproceedings{Liu20121AR,
  title={β1 Adrenergic Receptor Polymorphisms and Heart Failure: A Meta-Analysis on Susceptibility, Response to β-Blocker Therapy and Prognosis},
  author={Wen-Nan Liu and Kai-li Fu and Hongchang Gao and Yuan-yuan Shang and Zhihao Wang and Gui-hua Jiang and Yun Zhang and Wei Jun Zhang and Ming Zhong},
  booktitle={PloS one},
  year={2012}
}
AIMS The risk stratification of patients for heart failure (HF) remains a challenge, as well as the anticipation of the response to β-blocker therapy. Since the pivotal role of β1 adrenergic receptor (β1-AR) in HF, many publications have studied the associations between the β1-AR polymorphisms (Ser49Gly and Arg389Gly) and HF, with inconsistent results. Thus, we performed a meta-analysis of studies to evaluate the impact of β1-AR polymorphisms on susceptibility to HF, the response to β-blocker… CONTINUE READING

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