β1-Adrenergic Blockade Augments Pulsatile PTH Secretion in Humans

@article{Schmitt20031AdrenergicBA,
  title={β1-Adrenergic Blockade Augments Pulsatile PTH Secretion in Humans},
  author={Claus Peter Schmitt and Jennifer Obry and Reinhard Feneberg and Johannes D. Veldhuis and Otto Mehls and Eberhard Ritz and Franz Schaefer},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2003},
  volume={14 12},
  pages={3245-50}
}
Pulsatile peptide hormone secretion provides efficient control of specific end organ functions. To test the hypothesis that sympathetic neuronal activity drives synchronous pulsatile PTH release from the parathyroid glands, we investigated the acute effects of beta1-adrenergic receptor blockade on PTH secretion patterns in a single-blinded study in nine healthy adults. Plasma PTH levels were determined at 1-min intervals. After a 75-min baseline period, seven subjects received a continuous… CONTINUE READING

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