β1,4-Galactosyltransferase and Lactose Biosynthesis: Recruitment of a Housekeeping Gene from the Nonmammalian Vertebrate Gene Pool for a Mammary Gland Specific Function

@article{Shaper199814GalactosyltransferaseAL,
  title={β1,4-Galactosyltransferase and Lactose Biosynthesis: Recruitment of a Housekeeping Gene from the Nonmammalian Vertebrate Gene Pool for a Mammary Gland Specific Function},
  author={Nancy L. Shaper and Martin Charron and Neng-Wen Lo and Joel H. Shaper},
  journal={Journal of Mammary Gland Biology and Neoplasia},
  year={1998},
  volume={3},
  pages={315-324}
}
β1,4-galactosyltransferase (β4GalT-I)is a constitutively expressed trans-Golgi enzyme, widelydistributed in vertebrates, which synthesizes theβ4-N-acetyllactosamine structure commonly found in glycoconjugates. In mammals β4GalT-Ihas been recruited for a second biosynthetic function,the production of lactose; this function takes placeexclusively in the lactating mammary gland. Inpreparation for lactose biosynthesis, β4GalT-I enzymelevels are increased significantly. We show that mammalshave… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 27 references

Growth retardation and acidic protein gene expression in transgenic mice

  • S. Mink, E. Hartiag, P. Jennewein, W. Doppler
  • EMBO J .
  • 1997

Transcrip- position in the centromeric region of mouse chromosome 4. Cytogenet

  • B. Rajput, N. L. Shaper, J. H. Shaper
  • Cell Genet
  • 1996

Sequences of two highly divergentcanine type c lyso- Characterization of two cis-regulatory regions in the murine b 1,4-galactosyltr ansferase gene: Evidence for a negative regu

  • J. A. Grobler, K. R. Rao, S. Pervaiz, K. Brew
  • 1994

The 58enhancer of the mouse mammary

  • N. L. Shaper, A. Harduin-Leper s, J. H. Shaper
  • 1994

Genomic structure and expression of human b 1 , 4 - Glycoscience . galactosyltransfe rase

  • N. L. Shaper, J. H. Shaper
  • Biochem . Biophys . Res . Commun .
  • 1992

Similar Papers

Loading similar papers…