β-trefoil inhibitors--from the work of Kunitz onward.

@article{Renko2012trefoilIT,
  title={β-trefoil inhibitors--from the work of Kunitz onward.},
  author={Miha Renko and Jerica Saboti{\vc} and Dŭsan Turk},
  journal={Biological chemistry},
  year={2012},
  volume={393 10},
  pages={1043-54}
}
Protein protease inhibitors are the tools of nature in controlling proteolytic enzymes. They come in different shapes and sizes. The β-trefoil protease inhibitors that come from plants, first discovered by Kunitz, were later complemented with representatives from higher fungi. They inhibit serine (families S1 and S8) and cysteine proteases (families C1 and C13) as well as other hydrolases. Their versatility is the result of the plasticity of the loops coming out of the stable β-trefoil scaffold… CONTINUE READING

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