β-lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity

@inproceedings{Gutirrez2013lactamAP,
  title={β-lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity},
  author={Alejandro I. Barranco Guti{\'e}rrez and Luisa Laureti and Steve Crussard and Heni Abida and Alexandro Rodr{\'i}guez-Rojas and Jes{\'u}s Bl{\'a}zquez and Zeynep Baharoglu and Didier Mazel and Fabien Darfeuille and J{\"o}rg Vogel and Ivan Matic},
  booktitle={Nature communications},
  year={2013}
}
Regardless of their targets and modes of action, subinhibitory concentrations of antibiotics can have an impact on cell physiology and trigger a large variety of cellular responses in different bacterial species. Subinhibitory concentrations of β-lactam antibiotics cause reactive oxygen species production and induce PolIV-dependent mutagenesis in Escherichia coli. Here we show that subinhibitory concentrations of β-lactam antibiotics induce the RpoS regulon. RpoS-regulon induction is required… CONTINUE READING
Highly Cited
This paper has 131 citations. REVIEW CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 78 extracted citations

Unraveling the physiological complexities of antibiotic lethality.

Annual review of pharmacology and toxicology • 2015
View 17 Excerpts
Highly Influenced

131 Citations

0102030'14'16'18
Citations per Year
Semantic Scholar estimates that this publication has 131 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 71 references

Effect of recA inactivation on mutagenesis of Escherichia coli exposed to sublethal concentrations of antimicrobials

Thi, D T.
J. Antimicrob. Chemother • 2011

Hfq and its constellation of RNA

Nature Reviews Microbiology • 2011

a route towards multiresistance

Z. Baharoglu, Mazel, D. Vibrio cholerae triggers SOS, mutagenesis in response to a wide range of antibiotics
Antimicrob. Agents Chemother. 55, 2438–2441 • 2011