β-lactam antibiotics: An overview from a medicinal chemistry perspective.

@article{Lima2020lactamAA,
  title={$\beta$-lactam antibiotics: An overview from a medicinal chemistry perspective.},
  author={L{\'i}dia Moreira Lima and Bianca Nascimento Monteiro da Silva and Gisele Barbosa and Eliezer Jesus Barreiro},
  journal={European journal of medicinal chemistry},
  year={2020},
  volume={208},
  pages={
          112829
        }
}
β-Lactam antibiotics are one of the most relevant drug classes of antibacterial agents worldwide. The discovery and the market of first β-lactam antibiotic (Penicillin G) is a symbolic landmark of modern chemotherapy. Since then, several other β-lactam antibiotics have been introduced in the therapy, revolutionizing the treatment of bacterial infections. Their antibacterial efficacy has been kept in check by the emergence of bacterial resistance. Among the resistance mechanisms, the expression… Expand
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