β-d-glucosyl-hydroxymethyluracil: A novel modified base present in the DNA of the parasitic protozoan T. brucei

J. Gommers-Ampt; Fred M. van Leeuwen; A. J. D. Beer; J. Vliegenthart; P. Borst

DOI:10.1016/0092-8674(93)90322-H

Corpus ID: 24801094

β-d-glucosyl-hydroxymethyluracil: A novel modified base present in the DNA of the parasitic protozoan T. brucei

@article{GommersAmpt1993dglucosylhydroxymethyluracilAN,
  title={β-d-glucosyl-hydroxymethyluracil: A novel modified base present in the DNA of the parasitic protozoan T. brucei},
  author={J. Gommers-Ampt and Fred M. van Leeuwen and A. J. D. Beer and J. Vliegenthart and P. Borst},
  journal={Cell},
  year={1993},
  volume={75},
  pages={1129-1136}
}

J. Gommers-Ampt, Fred M. van Leeuwen, +2 authors P. Borst

Published 1993

Biology, Medicine

Cell

We have previously shown that the DNA of the unicellular eukaryote T. brucei contains about 0.1% of a novel modified base, called J. The presence of J correlates with a DNA modification associated with the silencing of telomeric expression sites for the variant surface antigens of trypanosomes. Here we show that J is 5-((beta-D-glucopyranosyloxy)-methyl)-uracil (shortened to beta-D-glucosyl-hydroxymethyluracil), a base not previously found in DNA. We discuss putative pathways for the… CONTINUE READING

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