β cells are responsible for CXCR3-mediated T-cell infiltration in insulitis

Abstract

T cell–mediated loss of insulin-secreting β cells in the islets of Langerhans is the hallmark of type 1 diabetes. The molecular basis for the directed migration of autoreactive T cells leading to insulitis is presently unknown. Here we demonstrate that in response to inflammation, β cells secrete the chemokines CXC ligand 10 and CXC ligand 9, which specifically attract T-effector cells via the CXC chemokine receptor 3. In mice deficient for this receptor, the onset of type 1 diabetes is substantially delayed. Thus, in the absence of known etiological agents, CXC receptor 3 represents a novel target for therapeutic interference early in type 1 diabetes.

DOI: 10.1038/nm1202-792
0100200300'04'06'08'10'12'14'16
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@article{Frigerio2002CA, title={β cells are responsible for CXCR3-mediated T-cell infiltration in insulitis}, author={Simona Frigerio and Tobias Junt and B. Lu and Craig J. Gerard and Urs W Zumsteg and Georg A. Holl{\"a}nder and Luca Piali}, journal={Nature Medicine}, year={2002}, volume={8}, pages={1414-1420} }