β-cell regeneration: the pancreatic intrinsic faculty.

@article{Desgraz2011cellRT,
  title={β-cell regeneration: the pancreatic intrinsic faculty.},
  author={Renaud Desgraz and Claire B. Bonal and Pedro L Herrera},
  journal={Trends in endocrinology and metabolism: TEM},
  year={2011},
  volume={22 1},
  pages={34-43}
}
Type I diabetes (T1D) patients rely on cumbersome chronic injections of insulin, making the development of alternate durable treatments a priority. The ability of the pancreas to generate new β-cells has been described in experimental diabetes models and, importantly, in infants with T1D. Here we discuss recent advances in identifying the origin of new β-cells after pancreatic injury, with and without inflammation, revealing a surprising degree of cell plasticity in the mature pancreas. In… CONTINUE READING

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