β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas.

@article{Damsky2011cateninSC,
  title={β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas.},
  author={William Damsky and David P. Curley and Manjula Santhanakrishnan and Lara E. Rosenbaum and James Platt and Bonnie Elyssa Gould Rothberg and Makoto Mark Taketo and David Dankort and David L. Rimm and Martin McMahon and Marcus C. Bosenberg},
  journal={Cancer cell},
  year={2011},
  volume={20 6},
  pages={741-54}
}
Malignant melanoma is characterized by frequent metastasis, however, specific changes that regulate this process have not been clearly delineated. Although it is well known that Wnt signaling is frequently dysregulated in melanoma, the functional implications of this observation are unclear. By modulating β-catenin levels in a mouse model of melanoma that is based on melanocyte-specific Pten loss and Braf(V600E) mutation, we demonstrate that β-catenin is a central mediator of melanoma… CONTINUE READING