β-catenin mediates stress resilience through Dicer1/microRNA regulation

@article{Dias2014cateninMS,
  title={β-catenin mediates stress resilience through Dicer1/microRNA regulation},
  author={C. Dias and Jian Feng and Haosheng Sun and Ning yi Shao and Michelle S Mazei-Robison and Diane Damez-Werno and Kimberly N. Scobie and Rosemary C. Bagot and Benoit Labont{\'e} and Efrain A. Ribeiro and Xiaochuan Liu and Pamela W Kennedy and Vincent F. Vialou and Deveroux Ferguson and Catherine Jensen Pe{\~n}a and Erin S. Calipari and Ja Wook Koo and Ezekiell A Mouzon and Subroto Ghose and Carol S Tamminga and Rachael Neve and Li Shen and Eric J Nestler},
  journal={Nature},
  year={2014},
  volume={516},
  pages={51-55}
}
β-catenin is a multi-functional protein that has an important role in the mature central nervous system; its dysfunction has been implicated in several neuropsychiatric disorders, including depression. Here we show that in mice β-catenin mediates pro-resilient and anxiolytic effects in the nucleus accumbens, a key brain reward region, an effect mediated by D2-type medium spiny neurons. Using genome-wide β-catenin enrichment mapping, we identify Dicer1—important in small RNA (for example… CONTINUE READING
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