β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis.

@article{Beyer2012cateninIA,
  title={β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis.},
  author={Christian Beyer and Amelie Schramm and Alfiya Akhmetshina and Clara Dees and Trayana Kireva and K Gelse and Sonali Sonnylal and Benoit de Crombrugghe and Makoto Mark Taketo and Oliver Distler and Georg Schett and Joerg H. W. Distler},
  journal={Annals of the rheumatic diseases},
  year={2012},
  volume={71 5},
  pages={761-7}
}
OBJECTIVES Pathologic fibroblast activation drives fibrosis of the skin and internal organs in patients with systemic sclerosis (SSc). β-catenin is an integral part of adherens junctions and a central component of canonical Wnt signaling. Here, the authors addressed the role of β-catenin in fibroblasts for the development of SSc dermal fibrosis. METHODS Nuclear accumulation of β-catenin in fibroblasts was assessed by triple staining for β-catenin, prolyl-4-hydroxylase-β and 4',6-diamidino-2… CONTINUE READING
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