β-catenin/Wnt signaling controls progenitor fate in the developing and regenerating zebrafish retina

@inproceedings{Meyers2012cateninWntSC,
  title={β-catenin/Wnt signaling controls progenitor fate in the developing and regenerating zebrafish retina},
  author={Jason Meyers and Lily Hu and Ariel Moses and Kavon Kaboli and Annemarie Papandrea and Pamela A. Raymond},
  booktitle={Neural Development},
  year={2012}
}
The zebrafish retina maintains two populations of stem cells: first, the germinal zone or ciliary marginal zone (CMZ) contains multipotent retinal progenitors that add cells to the retinal periphery as the fish continue to grow; second, radial glia (Müller cells) occasionally divide asymmetrically to generate committed progenitors that differentiate into rod photoreceptors, which are added interstitially throughout the retina with growth. Retinal injury stimulates Müller glia to dedifferentiate… CONTINUE READING

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Retinal injury stimulates Müller glia to dedifferentiate , re - enter the cell cycle , and generate multipotent retinal progenitors similar to those in the CMZ to replace missing neurons .
Retinal injury stimulates Müller glia to dedifferentiate , re - enter the cell cycle , and generate multipotent retinal progenitors similar to those in the CMZ to replace missing neurons .
RetinaIs associated anatomic site ofRetinal Diseases
Retinal injury stimulates Müller glia to dedifferentiate , re - enter the cell cycle , and generate multipotent retinal progenitors similar to those in the CMZ to replace missing neurons .
The zebrafish retina maintains two populations of stem cells : first , the germinal zone or ciliary marginal zone ( CMZ ) contains multipotent retinal progenitors that add cells to the retinal periphery as the fish continue to grow ; second , radial glia ( Müller cells ) occasionally divide asymmetrically to generate committed progenitors that differentiate into rod photoreceptors , which are added interstitially throughout the retina with growth .
The zebrafish retina maintains two populations of stem cells : first , the germinal zone or ciliary marginal zone ( CMZ ) contains multipotent retinal progenitors that add cells to the retinal periphery as the fish continue to grow ; second , radial glia ( Müller cells ) occasionally divide asymmetrically to generate committed progenitors that differentiate into rod photoreceptors , which are added interstitially throughout the retina with growth .
The zebrafish retina maintains two populations of stem cells : first , the germinal zone or ciliary marginal zone ( CMZ ) contains multipotent retinal progenitors that add cells to the retinal periphery as the fish continue to grow ; second , radial glia ( Müller cells ) occasionally divide asymmetrically to generate committed progenitors that differentiate into rod photoreceptors , which are added interstitially throughout the retina with growth .
The zebrafish retina maintains two populations of stem cells : first , the germinal zone or ciliary marginal zone ( CMZ ) contains multipotent retinal progenitors that add cells to the retinal periphery as the fish continue to grow ; second , radial glia ( Müller cells ) occasionally divide asymmetrically to generate committed progenitors that differentiate into rod photoreceptors , which are added interstitially throughout the retina with growth .
Retinal injury stimulates Müller glia to dedifferentiate , re - enter the cell cycle , and generate multipotent retinal progenitors similar to those in the CMZ to replace missing neurons .
The zebrafish retina maintains two populations of stem cells : first , the germinal zone or ciliary marginal zone ( CMZ ) contains multipotent retinal progenitors that add cells to the retinal periphery as the fish continue to grow ; second , radial glia ( Müller cells ) occasionally divide asymmetrically to generate committed progenitors that differentiate into rod photoreceptors , which are added interstitially throughout the retina with growth .
The zebrafish retina maintains two populations of stem cells : first , the germinal zone or ciliary marginal zone ( CMZ ) contains multipotent retinal progenitors that add cells to the retinal periphery as the fish continue to grow ; second , radial glia ( Müller cells ) occasionally divide asymmetrically to generate committed progenitors that differentiate into rod photoreceptors , which are added interstitially throughout the retina with growth .
The zebrafish retina maintains two populations of stem cells : first , the germinal zone or ciliary marginal zone ( CMZ ) contains multipotent retinal progenitors that add cells to the retinal periphery as the fish continue to grow ; second , radial glia ( Müller cells ) occasionally divide asymmetrically to generate committed progenitors that differentiate into rod photoreceptors , which are added interstitially throughout the retina with growth .
The zebrafish retina maintains two populations of stem cells : first , the germinal zone or ciliary marginal zone ( CMZ ) contains multipotent retinal progenitors that add cells to the retinal periphery as the fish continue to grow ; second , radial glia ( Müller cells ) occasionally divide asymmetrically to generate committed progenitors that differentiate into rod photoreceptors , which are added interstitially throughout the retina with growth .
Rod PhotoreceptorsConstitutional part ofRetina
The zebrafish retina maintains two populations of stem cells : first , the germinal zone or ciliary marginal zone ( CMZ ) contains multipotent retinal progenitors that add cells to the retinal periphery as the fish continue to grow ; second , radial glia ( Müller cells ) occasionally divide asymmetrically to generate committed progenitors that differentiate into rod photoreceptors , which are added interstitially throughout the retina with growth .
The zebrafish retina maintains two populations of stem cells : first , the germinal zone or ciliary marginal zone ( CMZ ) contains multipotent retinal progenitors that add cells to the retinal periphery as the fish continue to grow ; second , radial glia ( Müller cells ) occasionally divide asymmetrically to generate committed progenitors that differentiate into rod photoreceptors , which are added interstitially throughout the retina with growth .
The zebrafish retina maintains two populations of stem cells : first , the germinal zone or ciliary marginal zone ( CMZ ) contains multipotent retinal progenitors that add cells to the retinal periphery as the fish continue to grow ; second , radial glia ( Müller cells ) occasionally divide asymmetrically to generate committed progenitors that differentiate into rod photoreceptors , which are added interstitially throughout the retina with growth .
The zebrafish retina maintains two populations of stem cells : first , the germinal zone or ciliary marginal zone ( CMZ ) contains multipotent retinal progenitors that add cells to the retinal periphery as the fish continue to grow ; second , radial glia ( Müller cells ) occasionally divide asymmetrically to generate committed progenitors that differentiate into rod photoreceptors , which are added interstitially throughout the retina with growth .
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